Some types of accidents with 18 Wheelers include head on collisions, jack-knife accidents, truck drivers losing control of the vehicle, smaller vehicles sliding under the large trucks, and collision to the rear end and hit and run. Also, the blind spots on a truck are very large and accidents occur when the 18 Wheeler switches lanes.

There are trucking laws at the state and federal levels to ensure that truck drivers are well rested when operating the vehicle, as well as laws regarding the loading of cargo and the speeds at which the truck can travel. These laws are enforced to keep the truck driver and other people on the road safe.